The winner of the Man Booker Prize for literature is revealed later, with four-time hopeful Julian Barnes favourite for The Sense of an Ending.
While this year's shortlist has been the best-selling in Booker history, some in the literary world have accused the prize of becoming too populist.
The other nominees are Carol Birch, Patrick deWitt, Esi Edugyan, Stephen Kelman and AD Miller.
The £50,000 prize winner will be announced at London's Guildhall.
Bookmakers William Hill and Ladbrokes both have Barnes to win, with Birch's Jamrach's Menagerie as second favourite.
"We are bracing ourselves for a Booker battering as literary punters seem to believe Barnes is a banker bet," said Hill's spokesman Graham Sharpe.
Previous years have shown, however, that the Booker winner is notoriously hard to predict.
Last year Tom McCarthy's C had been the favourite to win, but the prize went to Howard Jacobson for his comic novel The Finkler Question.
When the final six novels were announced last month, this year's chair of judges, Dame Stella Rimington, said the focus was on readability.
"We wanted people to buy these books and read them, not buy them and admire them," said the former MI5 chief turned novelist,
But critics have accused the Booker judges of dumbing down, and one group of literary leading lights announced a rival award, The Literature Prize.
The award's backers claimed the Booker "now prioritises a notion of 'readability' over artistic achievement".
Ion Trewin, the Booker's literary director, dismissed the announcement as "a minor distraction".
"Do I detect sour grapes in some of those who support the possibility of a new literary prize, said to be a rival to the Man Booker?" he
wrote in the Telegraph on Monday.
But this year's judges faced more criticism from Sir Andrew Motion, who chaired the Booker panel in 2010.
The former poet laureate
told The Guardian the focus on readability "opens up a completely false divide between what is high end and what is readable, as if they are somehow in opposition to one other, which is patently not true".
Earlier in October, the New Statesman's lead fiction reviewer
Leo Robson wrote: "If things continue as they are, it isn't hard to imagine a time when the prize will be seen as a way not of celebrating novels, just of selling them."
William Hill said more than 50% of all bets on the Man Booker Prize had been for Julian Barnes, who has been shortlisted for the prize on three previous occasions, but without success.
The 65-year-old was nominated in 1984 for Flaubert's Parrot, in 1998 for England, England and in 2005 for Arthur and George.
Dark underbelly Barnes's novel The Sense of an Ending has a middle-aged man reflecting on the paths he and his childhood friends have taken as the past catches up with him via a bequeathed diary.
This year's shortlist contains two debut novelists, Miller and Kelman, as well as two women - Edugyan and Birch.
Two of the authors are Canadian - Edugyan and deWitt - while the other four are British. Four of the novels are from independent publishers.
Kelman's debut novel Pigeon English tells the story of an 11-year-old boy - recently arrived from from Ghana - who investigates the murder of a local boy on a tough London estate.
Miller's thriller Snowdrops, which reveals the dark underbelly of Moscow, was inspired by his time spent living in Russia.
Edugyan's Half-Blood Blues begins in 1930s Berlin with a jazz musician going missing as the Nazis take over the streets.
The Sisters Brothers, deWitt's second novel, is set against the backdrop of the 1850s Californian gold rush and is believed to be the first Western novel to feature on the shortlist.
Birch's novel, Jamrach's Menagerie, begins in the slums of Victorian London, and sends its protagonist Jaffy Brown on a whale ship bound for the Indian Ocean.
Sales of the six novels have exceeded those of any other Booker shortlist.
Snowdrops has been the bestselling book, shifting more than 28,500 copies between 4 September and 8 October, according to Nielsen BookScan.
In the same period, Jamrach's Menagerie sold more than 16,500 copies, The Sense of An Ending 12,500, Pigeon English 10,300, The Sisters Brothers 7,600, and Half Blood Blues almost 6,400.
Rimington's fellow Booker judges are writer and journalist Matthew d'Ancona, author Susan Hill, author and politician Chris Mullin and Gaby Wood of the Telegraph.